Your Guide to Replacing the Oxygen Sensors on a 2017-2022 Lexus RX350
Fix that check engine light and restore your RX350's fuel economy by choosing the right replacement oxygen sensor.
- Denso is the original equipment (OEM) manufacturer for Lexus; choosing a Denso or NGK/NTK sensor is the best choice for reliability.
- Your RX350 has four sensors; you must identify the correct location (Bank 1/2, Upstream/Downstream) before ordering a replacement.
- A bad oxygen sensor will trigger a check engine light and reduce your fuel economy.
- Ignoring a failed sensor can lead to damage to your expensive catalytic converters over time.
Is a Bad Oxygen Sensor a Serious Problem?

When an oxygen sensor fails on your RX350, your first warning is usually the check engine light. You might also notice your gas mileage getting worse or a rough feeling when the engine is idling. Some drivers report a rotten egg or sulfur smell from the exhaust, which is a sign of unburned fuel. While you can still drive the vehicle, ignoring a bad sensor for too long is not a good idea. The engine will run on an incorrect fuel mixture, which can eventually damage expensive parts like the spark plugs and catalytic converter.
Don't Ignore the Check Engine Light
A failing oxygen sensor is a common reason for the check engine light to come on. Continuing to drive with a bad sensor can lead to a failed emissions test and costly damage to your catalytic converter.
Understanding Your RX350's Oxygen Sensor Locations

Your 2017-2022 Lexus RX350 has a V6 engine with two cylinder banks and four sensors in total. Knowing which one has failed is the most important step before ordering a new part.
- Air/Fuel Ratio Sensors (Upstream): These are located before the catalytic converters, in the exhaust manifolds. They are the most critical for engine performance.
- Oxygen Sensors (Downstream): These are located after the catalytic converters. Their main job is to monitor the health of the converters.
- Bank 1: This is the cylinder bank located against the firewall (the wall between the engine and the passenger cabin). The sensors here are more difficult to access.
- Bank 2: This is the cylinder bank at the front of the engine bay, near the radiator. These sensors are much easier to access.
A mechanic's diagnostic scan tool will tell you exactly which sensor needs replacement (e.g., "Bank 1, Sensor 2").
Choosing the Right Aftermarket Oxygen Sensor

When it comes to sensors, quality matters. For a Lexus, sticking close to the original equipment (OEM) quality is the best approach. The original sensors on your RX350 are made by Denso.
Brand Quality Tiers for Lexus RX350
Tier 1: OEM-Level (Recommended)
- Denso: As the original supplier, a Denso-branded aftermarket sensor is a direct replacement for the factory part. They are manufactured to the strictest standards for performance and longevity. This is the safest choice for a first-time fit and reliable operation.
- NGK / NTK: NGK (under the NTK brand for sensors) is another top-tier Japanese manufacturer that supplies parts to many automakers. They are considered equal in quality to Denso and are an excellent, reliable alternative.
Tier 2: Reputable Aftermarket
- Bosch: Bosch is a massive, well-known parts manufacturer that invented the oxygen sensor. While their quality is generally good, some mechanics and Lexus owners in forums prefer to stick with Denso or NGK/NTK for Japanese vehicles to ensure perfect compatibility.
Tier 3: Budget-Friendly
- Walker Products, DriveWire: These brands offer a more affordable option. While they can work, they may not have the same longevity or precise calibration as the OEM-level brands. For a sensitive component like an oxygen sensor on a modern Lexus, investing in a Tier 1 brand is highly recommended to avoid future issues.
Common Ordering Mistake
The most common mistake is ordering the wrong sensor. Always confirm the exact location (Bank 1 or Bank 2, and Upstream or Downstream) from the diagnostic trouble code before you buy. The sensors have different wire lengths and connectors.
Cost to Replace a Lexus RX350 Oxygen Sensor

The cost depends on which of the four sensors needs replacing and who does the work.
| Item | Estimated Cost |
|---|---|
| New Aftermarket Oxygen Sensor | $63 - $175 |
| Shop Labor | $100 - $300+ |
| Total Professional Replacement | $163 - $475+ |
Note: Labor costs can be higher for the Bank 1 (firewall side) sensors, as they are much harder to reach. Dealer replacement costs will be significantly higher.
Frequently Asked Questions
Can I replace the oxygen sensor myself?
Yes, if you have some mechanical experience. The difficulty ranges from easy to very hard. The Bank 2 (front) sensors are accessible from the engine bay. The Bank 1 (rear) sensors are very difficult to reach and may require removing other components. You will need a special oxygen sensor socket to avoid damaging the wires.
How many oxygen sensors does my 2017-2022 RX350 have?
Your RX350 has four sensors: two Air/Fuel Ratio Sensors (upstream) and two Oxygen Sensors (downstream).
What's the difference between an Air/Fuel Sensor and an Oxygen Sensor?
They look similar, but they have different jobs. The upstream sensor is an Air/Fuel (A/F) Ratio Sensor, which provides more precise, faster readings to control the engine's fuel mixture. The downstream sensor is a traditional Oxygen (O2) Sensor that mainly checks if the catalytic converter is working. You cannot use them interchangeably.
My check engine light is on for an O2 sensor. Could it be something else?
Yes. Sometimes a code for an oxygen sensor can be triggered by another issue. On some Lexus models, water leaking from a clogged sunroof drain can get into electrical connectors inside the car, causing false oxygen sensor codes. It's always best to diagnose the problem correctly rather than just replacing parts.
Should I use a "universal" oxygen sensor?
It's not recommended. Universal sensors require you to cut and splice wires, which can create a weak point for failure. A direct-fit sensor from a quality brand like Denso or NGK/NTK costs a little more but is far more reliable and easier to install.
Helpful Videos
Technical Specifications
OEM Part Numbers: 89467-0E250 89467-48320 89465-0E210 89465-0E230 89465-48400 89465-48390 89467-0E240 89465-0E220 89467-48310 89465-48410
The 2017-2022 Lexus RX350 uses four heated, 4-wire sensors. The upstream sensors are wideband Air/Fuel Ratio sensors, while the downstream sensors are traditional oxygen sensors.
We Have This Part in Stock
The information in this article is provided for general reference and educational purposes only. Vehicle specifications, procedures, and part compatibility can vary by production date, trim level, and region. Always consult your vehicle's factory service manual and verify part numbers before purchasing or performing repairs. Safety-critical components such as airbags, seat belts, and braking systems should be installed by a qualified professional.
- Lexus RX350:
- 🎬 Helpful Videos
- 🛍️ Shop This Part
- Is a Bad Oxygen Sensor a Serious Problem?
- Don't Ignore the Check Engine Light
- Understanding Your RX350's Oxygen Sensor Locations
- Choosing the Right Aftermarket Oxygen Sensor
- Brand Quality Tiers for Lexus RX350
- Common Ordering Mistake
- Cost to Replace a Lexus RX350 Oxygen Sensor
- Frequently Asked Questions
- 🎟️ Get 5% Off