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GMC Sierra 2500 HD Fuse Box Replacement

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  1. ✓ In Stock 2016-2019 GMC Sierra 2500 HD Underhood Engine Fuse Box Assembly (Used OEM)

    2016-2019 GMC Sierra 2500 HD Underhood Engine Fuse Box Assembly (Used OEM)

    Partslink #: 646-11001

    It fits 4-door vehicles with a 5.3L engine and 6-speed automatic transmission. Please note that this fuse box assembly does not include relays, fuses, or fusible links.

    Condition: Excellent (A)
    Mileage: 59,100 miles

    $259.95 View part →
  2. ✓ In Stock 2015-2016 GMC Sierra 2500 HD Engine Fuse Box (Used OEM)

    2015-2016 GMC Sierra 2500 HD Engine Fuse Box (Used OEM)

    Partslink #: 646-01916

    It fits 4-door vehicles with a 5.3L engine and 6-speed automatic transmission. This assembly does not include relays, fuses, or fusible links.

    Condition: Excellent (A)
    Mileage: 143,100 miles

    $99.95 View part →
  3. ✓ In Stock 2014-2019 GMC Sierra 2500 HD Instrument Panel Junction Block Fuse Box (Used OEM)

    2014-2019 GMC Sierra 2500 HD Instrument Panel Junction Block Fuse Box (Used OEM)

    Partslink #: PB-9052-0000432526

    This is an instrument panel body wiring harness junction block box.

    Condition: Excellent (A)
    Mileage: 105,000 miles

    $99.95 View part →
  4. ✓ In Stock 2007 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2007 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8P07

    It fits vehicles with the 5.3L engine and 4-speed automatic transmission. This part is for 4-door models.

    Condition: Excellent (A)
    Mileage: 168,800 miles

    $105.95 View part →
  5. ✓ In Stock 2007-2014 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2007-2014 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8X07

    It fits vehicles with the 5.3L engine and 4-speed automatic transmission. This part is for 4-door models.

    Condition: Excellent (A)
    Mileage: 215,500 miles

    $105.95 View part →
  6. ✓ In Stock 2015-2019 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2015-2019 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8M15

    It fits vehicles with the 5.3L engine and 6-speed automatic transmission. This fuse box is for 4-door models and is located in the cabin.

    Condition: Excellent (A)
    Mileage: 62,200 miles

    $112.95 View part →
  7. ✓ In Stock 2015-2019 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2015-2019 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8M17

    It is for vehicles with the 5.3L engine and an automatic transmission. This part fits 4-door models.

    Condition: Excellent (A)
    Mileage: 61,600 miles

    $112.95 View part →
  8. ✓ In Stock 2019-2023 GMC Sierra 2500 HD Instrument Panel Cabin Fuse Box Junction Block (Used OEM)

    2019-2023 GMC Sierra 2500 HD Instrument Panel Cabin Fuse Box Junction Block (Used OEM)

    Partslink #: PB-9052-0000695940

    Condition: Good (B)
    Mileage: 144,000 miles

    $115.95 View part →
  9. ✓ In Stock 2015-2016 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2015-2016 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8M16

    It fits 4-door vehicles equipped with the 4.3L engine and a 6-speed automatic transmission. This is the cabin fuse box.

    Condition: Excellent (A)
    Mileage: 162,700 miles

    $119.95 View part →
  10. ✓ In Stock 2020-2023 GMC Sierra 2500 HD Engine Bay Battery Distribution Fuse Block (Used OEM)

    2020-2023 GMC Sierra 2500 HD Engine Bay Battery Distribution Fuse Block (Used OEM)

    Partslink #: PB-9052-0000695944

    It includes the battery distribution block and the positive battery jumper point.

    Condition: Good (B)
    Mileage: 144,000 miles

    $122.95 View part →
  11. ✓ In Stock 2020-2023 GMC Sierra 2500 HD Positive Battery Terminal Fuselink (Used OEM)

    2020-2023 GMC Sierra 2500 HD Positive Battery Terminal Fuselink (Used OEM)

    Partslink #: 646.GM9N20

    It is a fuselink for the positive battery terminal.

    Condition: Excellent (A)
    Mileage: 77,300 miles

    $122.95 View part →
  12. ✓ In Stock 2020-2023 GMC Sierra 2500 HD Battery Positive Cable Fuse Link (Used OEM)

    2020-2023 GMC Sierra 2500 HD Battery Positive Cable Fuse Link (Used OEM)

    Partslink #: 646.GM8323

    It features a fuse link on the positive cable. This part fits 4-door vehicles.

    Condition: Excellent (A)
    Mileage: 52,100 miles

    $122.95 View part →
  13. ✓ In Stock 2015-2019 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2015-2019 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8N16

    It is for 4-door vehicles equipped with the 6.6L engine and a 6-speed automatic transmission. This is the cabin fuse box.

    Condition: Excellent (A)
    Mileage: 135,700 miles

    $129.95 View part →
  14. ✓ In Stock 2007-2014 GMC Sierra 2500 HD Interior Fuse Box (Used OEM)

    2007-2014 GMC Sierra 2500 HD Interior Fuse Box (Used OEM)

    Partslink #: 663.GM9X11

    It fits vehicles with the 5.3L engine and 6-speed automatic transmission. For 4-door vehicles.

    Condition: Excellent (A)
    Mileage: 279,600 miles

    $129.95 View part →
  15. ✓ In Stock 2015-2019 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2015-2019 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM9M14

    It fits vehicles with the 5.3L engine and 6-speed automatic transmission. This fuse box is for 4-door models and is located in the cabin.

    Condition: Excellent (A)
    Mileage: 171,800 miles

    $139.95 View part →
  16. ✓ In Stock 2015-2019 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2015-2019 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM9M15

    It fits vehicles with the 5.3L engine and an automatic transmission. This part is for 4-door models.

    Condition: Excellent (A)
    Mileage: 117,600 miles

    $139.95 View part →
  17. ✓ In Stock 2015-2019 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2015-2019 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8M18

    It fits vehicles with the 5.3L engine and 6-speed automatic transmission. This fuse box is for 4-door models and is located in the cabin.

    Condition: Excellent (A)
    Mileage: 129,900 miles

    $139.95 View part →
  18. ✓ In Stock 2014 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2014 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8M14

    It fits vehicles with the 5.3L engine and an automatic transmission. This part is for 4-door models.

    Condition: Excellent (A)
    Mileage: 136,200 miles

    $139.95 View part →
  19. ✓ In Stock 2020-2023 GMC Sierra 2500 HD Instrument Panel Cabin Fuse Box Junction Block (Used OEM)

    2020-2023 GMC Sierra 2500 HD Instrument Panel Cabin Fuse Box Junction Block (Used OEM)

    Partslink #: PB-9052-0000531453

    It is a cabin fuse box junction block.

    Condition: Excellent (A)
    Mileage: 71,000 miles

    $153.95 View part →
  20. ✓ In Stock 2024-2025 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2024-2025 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM9N24

    It fits vehicles with the 6.6L engine and 10-speed automatic transmission. It is for vehicles with option code 4EC.

    Condition: Excellent (A)
    Mileage: 3,500 miles

    $173.95 View part →
  21. ✓ In Stock 2021-2023 GMC Sierra 2500 HD Engine Fuse Box (Used OEM)

    2021-2023 GMC Sierra 2500 HD Engine Fuse Box (Used OEM)

    Partslink #: 646-13186

    It is also called a power distribution junction block. This assembly does not include relays, fuses, or fusible links.

    Condition: Good (B)
    Mileage: 144,000 miles

    $185.95 View part →
  22. ✓ In Stock 2003-2006 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2003-2006 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8B04

    It is a cabin fuse box for vehicles with a 4.8L engine and a 4-speed automatic transmission. This part fits 4-door models.

    Condition: Excellent (A)
    Mileage: 246,000 miles

    $186.95 View part →
  23. ✓ In Stock 2021-2023 GMC Sierra 2500 HD Engine Fuse Box (Used OEM)

    2021-2023 GMC Sierra 2500 HD Engine Fuse Box (Used OEM)

    Partslink #: 646-13186

    It fits 4-door vehicles with the 6.6L engine and 10-speed automatic transmission. This part is for vehicles with a single fuel tank system. Please note that this fuse box assembly does not include relays, fuses, or fusible links.

    Condition: Excellent (A)
    Mileage: 52,100 miles

    $215.95 View part →
  24. ✓ In Stock 2024-2025 GMC Sierra 2500 HD Engine Compartment Fuse Box (Used OEM)

    2024-2025 GMC Sierra 2500 HD Engine Compartment Fuse Box (Used OEM)

    Partslink #: 646-13742

    For vehicles with the 6.6L engine and option code 4EC. This engine fuse box assembly does not include relays, fuses, or fusible links.

    Condition: Excellent (A)
    Mileage: 3,500 miles

    $215.95 View part →
  25. ✓ In Stock 2003-2006 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2003-2006 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8J05

    It is for vehicles with a 4-door body, a 5.3L engine, and a 4-speed automatic transmission.

    Condition: Excellent (A)
    Mileage: 268,700 miles

    $224.95 View part →
  26. ✓ In Stock 2006-2007 GMC Sierra 2500 HD Engine Fuse Box (Used OEM)

    2006-2007 GMC Sierra 2500 HD Engine Fuse Box (Used OEM)

    Partslink #: 646-01721

    It fits 4-door vehicles with the 5.3L engine and 4-speed automatic transmission. The internal circuit blocks are the same across different models, but the outer covers may vary by engine size.

    Condition: Excellent (A)
    Mileage: 308,000 miles

    $256.95 View part →
  27. ✓ In Stock 2007-2014 GMC Sierra 2500 HD Interior Fuse Box Junction Block (Used OEM)

    2007-2014 GMC Sierra 2500 HD Interior Fuse Box Junction Block (Used OEM)

    Partslink #: 663.GM8X13

    It fits 4-door vehicles with the 5.3L engine and automatic transmission.

    Condition: Excellent (A)
    Mileage: 140,000 miles

    $256.95 View part →
  28. ✓ In Stock 2007-2013 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2007-2013 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8X12

    It fits vehicles with the 5.3L engine and an automatic transmission. This part is for 4-door models.

    Condition: Excellent (A)
    Mileage: 144,500 miles

    $256.95 View part →
  29. ✓ In Stock 2015-2019 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2015-2019 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8N15

    It fits vehicles with the 6.6L engine and an automatic transmission. This part is for 4-door models.

    Condition: Excellent (A)
    Mileage: 114,400 miles

    $259.95 View part →
  30. ✓ In Stock 2007-2014 GMC Sierra 2500 HD Instrument Panel Cabin Fuse Box (Used OEM)

    2007-2014 GMC Sierra 2500 HD Instrument Panel Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM9X12

    It fits vehicles with the 5.3L engine and an automatic transmission. This part is for 4-door models.

    Condition: Excellent (A)
    Mileage: 148,200 miles

    $259.95 View part →
  31. ✓ In Stock 2007-2014 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2007-2014 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8X08

    It fits vehicles with the 5.3L engine and 4-speed automatic transmission. This part is for 4-door models.

    Condition: Excellent (A)
    Mileage: 183,800 miles

    $265.95 View part →
  32. ✓ In Stock 2007-2014 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2007-2014 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8X09

    It fits vehicles with the 4.8L engine and 4-speed automatic transmission. This part is for 4-door models.

    Condition: Excellent (A)
    Mileage: 188,800 miles

    $265.95 View part →
  33. ✓ In Stock 2003-2007 GMC Sierra 2500 HD Fuse Box (Used OEM)

    2003-2007 GMC Sierra 2500 HD Fuse Box (Used OEM)

    Partslink #: 663.GM6C03

    It fits vehicles with the 5.3L engine and 4-speed automatic transmission. This part is for 4-door models.

    Condition: Excellent (A)
    Mileage: 234,600 miles

    $265.95 View part →
  34. ✓ In Stock 2011-2014 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2011-2014 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM9Y11

    It fits vehicles with the 6.6L engine and an automatic transmission. This part is for 4-door models.

    Condition: Excellent (A)
    Mileage: 356,600 miles

    $265.95 View part →
  35. ✓ In Stock 2003-2006 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2003-2006 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8D04

    It fits vehicles with the 5.3L engine and 4-speed automatic transmission. This part is for 4-door models.

    Condition: Excellent (A)
    Mileage: 279,900 miles

    $265.95 View part →
  36. ✓ In Stock 2003-2007 GMC Sierra 2500 HD Fuse Box (Used OEM)

    2003-2007 GMC Sierra 2500 HD Fuse Box (Used OEM)

    Partslink #: 663.GM8M04

    It is for vehicles with the 5.3L engine and an automatic transmission. This part fits 4-door models.

    Condition: Excellent (A)
    Mileage: 165,700 miles

    $265.95 View part →
  37. ✓ In Stock 2020-2023 GMC Sierra 2500 HD Fuse Box (Used OEM)

    2020-2023 GMC Sierra 2500 HD Fuse Box (Used OEM)

    Partslink #: 663.GM8322

    It fits vehicles with the 6.6L engine and 6-speed automatic transmission. This part is for 4-door models.

    Condition: Excellent (A)
    Mileage: 51,400 miles

    $279.95 View part →
  38. ✓ In Stock 2021-2022 GMC Sierra 2500 HD Engine Bay Fuse Box (Used OEM)

    2021-2022 GMC Sierra 2500 HD Engine Bay Fuse Box (Used OEM)

    Partslink #: 646-13204

    It is for vehicles with the 6.6L engine and 6-speed automatic transmission. This part is for 4-door vehicles. Please verify that your part identification number matches. Note: This fuse box assembly does not include relays, fuses, or fusible links.

    Condition: Excellent (A)
    Mileage: 51,400 miles

    $279.95 View part →
  39. ✓ In Stock 2015-2019 GMC Sierra 2500 HD Cabin Fuse Box with Power Adjustable Pedals (Used OEM)

    2015-2019 GMC Sierra 2500 HD Cabin Fuse Box with Power Adjustable Pedals (Used OEM)

    Partslink #: 663.GM9M16

    It fits vehicles with the 4.3L engine and 6-speed automatic transmission. This part is for 4-door models.

    Condition: Excellent (A)
    Mileage: 185,500 miles

    $279.95 View part →
  40. ✓ In Stock 2020-2023 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    2020-2023 GMC Sierra 2500 HD Cabin Fuse Box (Used OEM)

    Partslink #: 663.GM8M21

    It fits vehicles with the 3.0L engine and 10-speed automatic transmission. This part is for 4-door models.

    Condition: Excellent (A)
    Mileage: 48,900 miles

    $279.95 View part →
  41. ✓ In Stock 2005 GMC Sierra 2500 HD Engine Fuse Box (Used OEM)

    2005 GMC Sierra 2500 HD Engine Fuse Box (Used OEM)

    Partslink #: 646-01436

    For 4-door vehicles with the 5.3L engine and 4-speed automatic transmission. The cover differs for 2005 through 2006 SUVs, so you may need to switch the cover as needed.

    Condition: Excellent (A)
    Mileage: 263,700 miles

    $289.95 View part →
  42. ✓ In Stock 2011-2014 GMC Sierra 2500 HD Fuse Box (Used OEM)

    2011-2014 GMC Sierra 2500 HD Fuse Box (Used OEM)

    Partslink #: 663.GM8Z13

    It fits vehicles with the 6.0L engine and 6-speed automatic transmission. It is for vehicles with option code 2RC.

    Condition: Excellent (A)
    Mileage: 735,000 miles

    $299.95 View part →
  43. ✓ In Stock 2020-2022 GMC Sierra 2500 HD Underhood Engine Fuse Box Assembly (Used OEM)

    2020-2022 GMC Sierra 2500 HD Underhood Engine Fuse Box Assembly (Used OEM)

    Partslink #: 646-12380

    It is for 4-door vehicles with the 6.6L engine. This fuse box assembly does not include relays, fuses, or fusible links. It is for vehicles with a single fuel tank system and without the automatic engine stop and start feature.

    Condition: Excellent (A)
    Mileage: 77,300 miles

    $479.95 View part →

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Fuse Box Compatibility for GMC Sierra 2500 HD

Browse our selection of quality fuse box parts designed specifically for your GMC Sierra 2500 HD. We carry options across multiple trim levels, body styles, and engine configurations to ensure a perfect fit.

Available Trims

AT4 · AT4X · Base · Denali · Denali Ultimate · Pro · SL · SLE · SLT · WT

Body Types

Crew Cab Pickup · Extended Cab Pickup · Standard Cab Pickup

Engine Options

V8 6.0L · V8 6.6L · V8 8.1L

Transmissions

Automatic · Manual

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